SCHEMBL21732287

SCHEMBL21732287

CONc1ccc(N2CCOCC2c2ccc(C(F)(F)F)cc2)nc1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 9/20 0.51
HDAC8 Q9BY41 8/20 0.51
HDAC1 Q13547 6/20 0.51
MAPT P10636 5/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
STAT3 P40763 1/20 0.46
HDAC5 Q9UQL6 2/20 0.42
KDM4E B2RXH2 1/20 0.40
TMEM97 Q5BJF2 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
ALDH1A1 P00352 1/20 0.39
GAA P10253 1/20 0.38
MCHR1 Q99705 1/20 0.37
NUDT1 P36639 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21732260 0.88 HDAC6 (0.41) HDAC6HDAC8HDAC1MAPTSMN1; SMN2
SCHEMBL21732286 0.86 HDAC6 (0.44) HDAC6HDAC8HDAC1MAPTSMN1; SMN2
SCHEMBL20319884 0.79 HDAC6 (0.53) HDAC6HDAC8HDAC1MAPTSMN1; SMN2
SCHEMBL21732201 0.79 HDAC6 (0.44) HDAC6HDAC8HDAC1MAPTSMN1; SMN2
SCHEMBL21723217 0.76 HDAC6 (0.48) HDAC6HDAC8HDAC1HDAC5NUDT1
SCHEMBL30016555 0.72 HDAC6 (0.43) HDAC6HDAC8HDAC1HDAC5NUDT1
SCHEMBL21723124 0.71 HDAC6 (0.41) HDAC6HDAC8HDAC1MAPTSMN1; SMN2
SCHEMBL20319854 0.71 HDAC6 (0.41) HDAC6HDAC8HDAC1MAPTSMN1; SMN2
SCHEMBL30016611 0.69 HDAC6 (0.43) HDAC6HDAC8HDAC1HDAC5NUDT1
SCHEMBL30017681 0.69 HDAC6 (0.43) HDAC6HDAC8HDAC1HDAC5NUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020035557-A1 NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA LEO PHARMA A/S (DK) 2020-02-20 WO disclosed