SCHEMBL21732201

SCHEMBL21732201

CONc1ccc(N2CCOCC2c2cccc(Cl)c2)nc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 8/20 0.44
HDAC8 Q9BY41 7/20 0.44
HDAC1 Q13547 5/20 0.44
NTRK1 P04629 1/20 0.40
NTRK3 Q16288 1/20 0.40
NTRK2 Q16620 1/20 0.40
DGAT1 O75907 1/20 0.40
PIK3C3 Q8NEB9 2/20 0.39
CNR2 P34972 2/20 0.39
HDAC5 Q9UQL6 2/20 0.38
NUDT1 P36639 1/20 0.38
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
MDM2 Q00987 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21732287 0.79 HDAC6 (0.51) HDAC6HDAC8HDAC1HDAC5NUDT1
SCHEMBL21732189 0.73 RORC (0.48)
SCHEMBL21732190 0.72 RORC (0.35) HDAC6HDAC8HDAC1DGAT1
SCHEMBL21732073 0.72 MEN1 (0.42) NTRK1PIK3C3SMN1; SMN2MAOAMAOB
SCHEMBL21732282 0.69 NTRK1 (0.40) HDAC6HDAC8HDAC1NTRK1NTRK3
SCHEMBL4582373 0.67 CDK2 (0.52) NTRK2NUDT1
SCHEMBL4582377 0.67 CDK2 (0.52) NTRK2NUDT1
SCHEMBL21732260 0.66 HDAC6 (0.41) HDAC6HDAC8HDAC1NUDT1MAPT
SCHEMBL20319863 0.65 HDAC6 (0.45) HDAC6HDAC8HDAC1CNR2HDAC5
SCHEMBL21732286 0.65 HDAC6 (0.44) HDAC6HDAC8HDAC1HDAC5NUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020035557-A1 NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA LEO PHARMA A/S (DK) 2020-02-20 WO disclosed