Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 13/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21711976 | 0.91 | WDR5 (0.42) | WDR5NAMPTAKT1HDAC6L3MBTL1 | |
| SCHEMBL21732376 | 0.84 | WDR5 (0.49) | WDR5 | |
| SCHEMBL21817493 | 0.80 | DHODH (0.50) | WDR5DHODH | |
| SCHEMBL21711775 | 0.77 | WDR5 (0.48) | WDR5NAMPTHDAC1L3MBTL1 | |
| SCHEMBL21711940 | 0.76 | WDR5 (0.49) | WDR5 | |
| SCHEMBL21711962 | 0.76 | WDR5 (0.49) | WDR5 | |
| SCHEMBL16147999 | 0.75 | HDAC1 (0.46) | NAMPTHDAC1L3MBTL1 | |
| SCHEMBL15861836 | 0.75 | HDAC1 (0.46) | NAMPTHDAC1L3MBTL1 | |
| SCHEMBL545480 | 0.75 | CACNA1H (0.48) | NAMPTHDAC1P2RY14 | |
| SCHEMBL21711946 | 0.74 | KCNH2 (0.52) | WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807959-B2 | WDR5-MLL1 inhibitors and modulators | VANDERBILT UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| US-20200055824-A1 | WDR5-MLL1 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807959-B2 | WDR5-MLL1 inhibitors and modulators | WDR5, WDR1, WDR3 | WDR5 1/4885DHODH 2433/4885NAMPT 2345/4885 |
| US-20200055824-A1 | WDR5-MLL1 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | WDR5 1/4885DHODH 2433/4885NAMPT 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.