Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18408662 | 0.84 | MAPT (0.58) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL16746095 | 0.80 | MAPT (0.44) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL20315037 | 0.79 | MAPT (0.43) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL19304119 | 0.79 | NOS1 (0.50) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL26290444 | 0.75 | MAPT (0.40) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL23564658 | 0.71 | MAPT (0.43) | MAPTALDH1A1HTTNOS1PTK2 | |
| SCHEMBL21733576 | 0.71 | MAPT (0.43) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL25510943 | 0.70 | MAPT (0.42) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL24648990 | 0.69 | MAPT (0.49) | MAPTALDH1A1HTTNOS1KDM4E | |
| SCHEMBL20883608 | 0.68 | NOS1 (0.46) | MAPTALDH1A1HTTNOS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |