SCHEMBL21734883

SCHEMBL21734883

CCc1cc(Cl)ccc1NC(=O)OC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.44
PTGER1 P34995 2/20 0.44
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
CYP2C9 P11712 1/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
GAA P10253 2/20 0.42
HPGD P15428 3/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
TP53 P04637 1/20 0.40
GLA P06280 1/20 0.40
XBP1 P17861 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HSD17B10 Q99714 1/20 0.40
KDM4E B2RXH2 1/20 0.40
PKM P14618 1/20 0.40
ALOX12 P18054 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1196841 0.90 GAA (0.44) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL29927204 0.90 GAA (0.44) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL23254120 0.89 IDO1 (0.43) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL31718056 0.87 SLC6A4 (0.43) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL18104501 0.87 MAPT (0.42) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL16799845 0.87 SLC6A4 (0.43) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL5729946 0.85 PTGER1 (0.45) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL8760784 0.85 PTGER1 (0.41) IDO1PTGER1HSP90AA1HSP90AB1CYP2C9
SCHEMBL12074983 0.84 HPGD (0.50) CYP2C9KMT2AMEN1GAAHPGD
SCHEMBL3787046 0.84 KMT2A (0.54) IDO1HSP90AA1HSP90AB1CYP2C9KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3447050-B1 PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS INC (US) 2020-02-19 EP disclosed