Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8760784 | 0.89 | PTGER1 (0.41) | PTGER1IDO1TP53SMN1; SMN2HSP90AA1 | |
| SCHEMBL8762247 | 0.86 | PTGER1 (0.46) | PTGER1IDO1TP53SMN1; SMN2HSP90AA1 | |
| SCHEMBL21734883 | 0.85 | IDO1 (0.44) | PTGER1IDO1TP53HSP90AA1HSP90AB1 | |
| SCHEMBL1196841 | 0.84 | GAA (0.44) | PTGER1IDO1TP53HSP90AA1HSP90AB1 | |
| SCHEMBL29927204 | 0.84 | GAA (0.44) | PTGER1IDO1TP53HSP90AA1HSP90AB1 | |
| SCHEMBL23254120 | 0.83 | IDO1 (0.43) | PTGER1IDO1TP53SMN1; SMN2HSP90AA1 | |
| SCHEMBL31718056 | 0.82 | SLC6A4 (0.43) | PTGER1IDO1HSP90AA1HSP90AB1CYP2C9 | |
| SCHEMBL18104501 | 0.82 | MAPT (0.42) | PTGER1IDO1TP53HSP90AA1HSP90AB1 | |
| SCHEMBL16799845 | 0.82 | SLC6A4 (0.43) | PTGER1IDO1HSP90AA1HSP90AB1CYP2C9 | |
| SCHEMBL6628806 | 0.81 | PDK1 (0.56) | IDO1SMN1; SMN2HSP90AA1HSP90AB1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501826-B1 | SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | EP | disclosed |
| US-6852726-B2 | Substituted indoles as alpha-1 agonists | SYNTEX LLC (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1501826-A2 | SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS | F. Hoffman-la Roche AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| US-20030220319-A1 | Substituted indoles as alpha-1 agonists | SYNTEX (U.S.A.) LLC | 2003-11-27 | — | — | US | disclosed |
| WO-2003064387-A2 | SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220319-A1 | Substituted indoles as alpha-1 agonists | ADRA1A, ADRB1, ADRA1B | PTGER1 146/4885IDO1 207/4885TP53 4319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.