Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21733010 | 0.91 | JAK2 (0.42) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL21733007 | 0.90 | TLR7 (0.37) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL21733006 | 0.85 | TLR7 (0.38) | TLR7TLR8 | |
| SCHEMBL21732874 | 0.85 | TLR7 (0.33) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL21732872 | 0.84 | NLRP3 (0.35) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL21732875 | 0.84 | TLR7 (0.33) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL21732900 | 0.84 | GRM2 (0.34) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL21732904 | 0.83 | TLR7 (0.37) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL23916902 | 0.82 | JAK1 (0.40) | TLR7TLR8JAK2JAK1NLRP3 | |
| SCHEMBL21724254 | 0.81 | NLRP3 (0.49) | TLR7TLR8JAK2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037092-A1 | IMIDAZO[4,5-C]QUINOLINE DERIVED NLRP3-MODULATORS | INNATE TUMOR IMMUNITY, INC. (US) | 2020-02-20 | — | — | WO | disclosed |