Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 3/20 | 0.68 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.62 |
| ▸ | SETD2 | Q9BYW2 | 3/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | DDO | Q99489 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24019706 | 0.82 | NSD2 (0.64) | NSD2SMYD3SETD2HRH4DAO | |
| SCHEMBL26098927 | 0.81 | NSD2 (1.00) | NSD2SMYD3SETD2HRH4NPC1 | |
| SCHEMBL18354217 | 0.80 | NSD2 (0.61) | NSD2SMYD3SETD2HRH4DAO | |
| SCHEMBL2042234 | 0.80 | NSD2 (0.66) | NSD2SMYD3SETD2HRH4DAO | |
| SCHEMBL3283667 | 0.79 | NSD2 (0.61) | NSD2SMYD3SETD2HRH4DAO | |
| SCHEMBL28399059 | 0.79 | NSD2 (0.60) | NSD2SMYD3SETD2HRH4DAO | |
| SCHEMBL29609758 | 0.79 | NSD2 (0.60) | NSD2SMYD3SETD2HRH4DAO | |
| SCHEMBL21739507 | 0.79 | NSD2 (0.60) | NSD2SMYD3SETD2HRH4DAO | |
| SCHEMBL25040319 | 0.78 | SMYD3 (0.80) | NSD2SMYD3SETD2HRH4HDAC3 | |
| SCHEMBL25037859 | 0.78 | SMYD3 (0.80) | NSD2SMYD3SETD2HRH4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261243-A1 | COMBINATION THERAPIES WITH SETD2 INHIBITORS | Epizyme, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |
| WO-2020112872-A1 | METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2 | Epizyme, Inc. (US) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |