Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 3/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.57 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | DDO | Q99489 | 1/20 | 0.54 |
| ▸ | SETD2 | Q9BYW2 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28399059 | 1.00 | NSD2 (0.60) | NSD2HRH4SMYD3DAODDO | |
| SCHEMBL2042234 | 0.84 | NSD2 (0.66) | NSD2HRH4SMYD3DAODDO | |
| SCHEMBL18354217 | 0.84 | NSD2 (0.61) | NSD2HRH4SMYD3DAODDO | |
| SCHEMBL25139601 | 0.80 | NSD2 (0.57) | NSD2HRH4SMYD3DAODDO | |
| SCHEMBL3283667 | 0.80 | NSD2 (0.61) | NSD2HRH4SMYD3DAODDO | |
| SCHEMBL7884356 | 0.79 | NSD2 (0.50) | NSD2HRH4SMYD3DAODDO | |
| SCHEMBL7942068 | 0.79 | HRH4 (0.57) | HRH4DAODDOHSD17B10ALDH1A1 | |
| SCHEMBL29063451 | 0.79 | HRH4 (0.56) | HRH4DAOKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL30310556 | 0.79 | HRH4 (0.56) | HRH4DAOKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL21739100 | 0.79 | NSD2 (0.68) | NSD2HRH4SMYD3DAODDO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099424-A1 | Nitrile-Containing Antiviral Compounds | PFIZER INC. (US) | 2025-03-27 | — | — | US | disclosed |
| US-20240299352-A1 | COMBINATION THERAPIES WITH SETD2 INHIBITORS | Epizyme, Inc. | 2024-09-12 | — | — | US | disclosed |
| US-20230133671-A1 | SETD2 INHIBITORS AND RELATED METHODS AND USES, INCLUDING COMBINATION THERAPIES | Epizyme, Inc. (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230120254-A1 | Nitrile-Containing Antiviral Compounds | PFIZER INC. (US) | 2023-04-20 | — | — | US | disclosed |
| US-11452711-B2 | Nitrile-containing antiviral compounds | PFIZER INC. (US) | 2022-09-27 | — | — | US | disclosed |
| US-20220257563-A1 | Nitrile-Containing Antiviral Compounds | PFIZER INC. (US) | 2022-08-18 | — | — | US | disclosed |
| US-11351149-B2 | Nitrile-containing antiviral compounds | PFIZER INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20220142976-A1 | Nitrile-Containing Antiviral Compounds | PFIZER INC. (US) | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220257563-A1 | Nitrile-Containing Antiviral Compounds | ACE2, NOS2, EIF2AK2 | NSD2 60/4885HRH4 3235/4885SMYD3 2065/4885 |
| US-11452711-B2 | Nitrile-containing antiviral compounds | ACE2, NOS2, EIF2AK2 | NSD2 60/4885HRH4 3235/4885SMYD3 2065/4885 |
| US-20230120254-A1 | Nitrile-Containing Antiviral Compounds | ACE2, NOS2, EIF2AK2 | NSD2 60/4885HRH4 3235/4885SMYD3 2065/4885 |
| US-20250099424-A1 | Nitrile-Containing Antiviral Compounds | ACE2, NOS2, EIF2AK2 | NSD2 60/4885HRH4 3235/4885SMYD3 2065/4885 |
| US-20220142976-A1 | Nitrile-Containing Antiviral Compounds | ACE2, NOS2, EIF2AK2 | NSD2 60/4885HRH4 3235/4885SMYD3 2065/4885 |
| US-20240299352-A1 | COMBINATION THERAPIES WITH SETD2 INHIBITORS | SETD2, CARM1, SETDB1 | NSD2 35/4885HRH4 4351/4885SMYD3 386/4885 |
| US-11351149-B2 | Nitrile-containing antiviral compounds | ACE2, NOS2, EIF2AK2 | NSD2 60/4885HRH4 3235/4885SMYD3 2065/4885 |
| US-20230133671-A1 | SETD2 INHIBITORS AND RELATED METHODS AND USES, INCLUDING COMBINATION THERAPIES | EZH2, HDAC2, SETD2 | NSD2 14/4885HRH4 3102/4885SMYD3 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.