Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 10/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040139 | 0.86 | GPR35 (0.52) | GAADHODHALDH1A1LMNAMAPT | |
| SCHEMBL4040130 | 0.86 | GPR35 (0.52) | GAADHODHALDH1A1LMNAMAPT | |
| SCHEMBL4040135 | 0.86 | GPR35 (0.52) | GAADHODHALDH1A1LMNAMAPT | |
| SCHEMBL5361515 | 0.86 | GAA (0.46) | GAADHODHALDH1A1LMNAMAPT | |
| SCHEMBL5361513 | 0.86 | GAA (0.46) | GAADHODHALDH1A1LMNAMAPT | |
| SCHEMBL7943758 | 0.85 | GAA (0.62) | GAAALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL7877752 | 0.85 | GAA (0.62) | GAAALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL20794418 | 0.85 | GAA (0.56) | GAADHODHALDH1A1LMNAMAPT | |
| SCHEMBL14019452 | 0.85 | GAA (0.56) | GAADHODHALDH1A1LMNAMAPT | |
| SCHEMBL11770571 | 0.85 | GAA (0.56) | GAADHODHALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |