SCHEMBL21744944 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	CKS1B	P61024	2/20	0.49

▸	SKP1	P63208	2/20	0.49

▸	SKP2	Q13309	2/20	0.49

▸	GPR119	Q8TDV5	7/20	0.48

▸	MAP4K4	O95819	1/20	0.47

▸	SUV39H2	Q9H5I1	2/20	0.46

▸	POLB	P06746	1/20	0.44

▸	MEN1	O00255	3/20	0.44

▸	KMT2A	Q03164	3/20	0.44

▸	MAPT	P10636	2/20	0.43

▸	ALDH1A1	P00352	1/20	0.43

▸	LMNA	P02545	1/20	0.43

▸	TSHR	P16473	1/20	0.43

▸	SMN1; SMN2	Q16637	1/20	0.43

▸	RET	P07949	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1280129	0.87	GPR119 (0.56)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL3991539	0.86	CKS1B (0.50)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL17310093	0.85	SUV39H2 (0.49)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL29668815	0.85	GPR119 (0.48)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL1579594	0.85	CKS1B (0.50)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL1580434	0.85	GPR119 (0.48)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL24851452	0.85	CKS1B (0.49)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL22309127	0.85	CKS1B (0.49)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL30162245	0.85	CKS1B (0.49)	CKS1BSKP1SKP2GPR119MAP4K4
SCHEMBL24851455	0.84	CKS1B (0.53)	CKS1BSKP1SKP2GPR119MAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2020035065-A1	PYRAZOLE DERIVATIVE AS RET INHIBITOR	南京明德新药研发有限公司	2020-02-20	—	—	WO	disclosed