Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | OGA | O60502 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12680212 | 0.87 | LMNA (0.53) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL25560876 | 0.84 | LMNA (0.50) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL23957682 | 0.82 | LMNA (0.48) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL20372859 | 0.82 | LMNA (0.48) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL28938107 | 0.78 | LMNA (0.51) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL23352193 | 0.76 | LMNA (0.45) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL24724171 | 0.75 | KDM4E (0.44) | LMNAKMT2AKDM4EALDH1A1OGA | |
| SCHEMBL31516755 | 0.75 | KDM4E (0.58) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL861501 | 0.75 | LMNA (0.61) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL46317 | 0.75 | KDM4E (0.58) | LMNAKMT2AKDM4EALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035065-A1 | PYRAZOLE DERIVATIVE AS RET INHIBITOR | 南京明德新药研发有限公司 | 2020-02-20 | — | — | WO | disclosed |