Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19643216 | 0.86 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19643508 | 0.83 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL19643540 | 0.79 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL21747768 | 0.77 | ROCK2 (0.71) | ROCK2 | |
| SCHEMBL19644088 | 0.74 | ROCK2 (0.81) | ROCK2 | |
| SCHEMBL19643690 | 0.73 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19644061 | 0.73 | ROCK2 (0.87) | ROCK2 | |
| SCHEMBL19644043 | 0.72 | ROCK2 (0.88) | ROCK2 | |
| SCHEMBL19643947 | 0.69 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL19643214 | 0.69 | ROCK2 (1.00) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464262-B1 | TRIAZOLONES AND TETRAZOLONES AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2020-02-26 | — | — | EP | disclosed |