Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747908 | 0.91 | JAK3 (0.50) | JAK3HTR2AHTR2CROCK1ROCK2 | |
| SCHEMBL21753142 | 0.89 | CHRM4 (0.37) | JAK3HTR2AHTR2CROCK1ROCK2 | |
| SCHEMBL29700778 | 0.89 | CHRM4 (0.37) | JAK3HTR2AHTR2CROCK1ROCK2 | |
| SCHEMBL21747965 | 0.85 | ALK (0.37) | JAK3HTR2AHTR2CFGFR4BTK | |
| SCHEMBL21761227 | 0.81 | JAK3 (0.53) | JAK3HTR2AHTR2CROCK1ROCK2 | |
| SCHEMBL21747833 | 0.80 | JAK3 (0.51) | JAK3HTR2AHTR2CROCK1ROCK2 | |
| SCHEMBL21747950 | 0.80 | BTK (0.38) | KDM4EFGFR4BTKCYP11B2MAPT | |
| SCHEMBL21760537 | 0.77 | S1PR1 (0.49) | JAK3CYP11B2 | |
| SCHEMBL29700827 | 0.77 | S1PR1 (0.49) | JAK3CYP11B2 | |
| SCHEMBL21747910 | 0.77 | BTK (0.47) | JAK3FGFR4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613738-A1 | 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER | Lead Discovery Center GmbH (DE) | 2020-02-26 | — | — | EP | disclosed |