Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 8/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747965 | 0.94 | ALK (0.37) | BTKALKCYP11B2FGFR4 | |
| SCHEMBL29700822 | 0.91 | BTK (0.48) | BTKCREBBPALKCYP11B2BRD4 | |
| SCHEMBL21747991 | 0.91 | BTK (0.48) | BTKCREBBPALKCYP11B2BRD4 | |
| SCHEMBL21753139 | 0.88 | BRD4 (0.38) | BTKCREBBPALKCYP11B2BRD4 | |
| SCHEMBL29700787 | 0.88 | BRD4 (0.38) | BTKCREBBPALKCYP11B2BRD4 | |
| SCHEMBL21747910 | 0.85 | BTK (0.47) | BTKFGFR4 | |
| SCHEMBL21747850 | 0.83 | PDE3B (0.39) | ALKMAPTFGFR4 | |
| SCHEMBL21753141 | 0.82 | CHRM4 (0.37) | ALKCYP11B2FGFR4 | |
| SCHEMBL29700791 | 0.82 | CHRM4 (0.37) | ALKCYP11B2FGFR4 | |
| SCHEMBL21747867 | 0.80 | JAK3 (0.40) | BTKCYP11B2KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613738-A1 | 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER | Lead Discovery Center GmbH (DE) | 2020-02-26 | — | — | EP | disclosed |