Tryptophan

Tryptophan

SCHEMBL2174795

N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.O=C(O)C(=O)Cc1c[nH]c2ccccc12

nearest known ligand 0.82

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.82
MAPT P10636 4/20 0.82
KMT2A Q03164 4/20 0.82
MEN1 O00255 3/20 0.82
LMNA P02545 2/20 0.82
TSHR P16473 2/20 0.82
BLM P54132 2/20 0.82
PMP22 Q01453 2/20 0.82
MPO P05164 1/20 0.82
HIF1A Q16665 1/20 0.82
SMN1; SMN2 Q16637 2/20 0.74
ALDH1A1 P00352 2/20 0.74
HPGD P15428 1/20 0.74
SLC6A2 P23975 2/20 0.59
FNTA P49354 1/20 0.59
FNTB P49356 1/20 0.59
APAF1 O14727 1/20 0.58
POLB P06746 1/20 0.58
RECQL P46063 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Tryptophan SCHEMBL2176030 1.00 KDM4E (0.82) KDM4EMAPTKMT2AMEN1LMNA
Dl-Tryptophan SCHEMBL2174790 1.00 KDM4E (0.82) KDM4EMAPTKMT2AMEN1LMNA
Dl-Tryptophan SCHEMBL28034780 0.93 KMT2A (0.78) KDM4EMAPTKMT2AMEN1LMNA
Tryptophan SCHEMBL29884112 0.93 KMT2A (0.78) KDM4EMAPTKMT2AMEN1LMNA
Dl-Tryptophan SCHEMBL21059258 0.91 KMT2A (0.94) KDM4EMAPTKMT2AMEN1LMNA
Tryptophan SCHEMBL31214183 0.91 KMT2A (0.94) KDM4EMAPTKMT2AMEN1LMNA
Tryptophan SCHEMBL23141133 0.91 KMT2A (1.00) KDM4EMAPTKMT2AMEN1LMNA
Tryptophan SCHEMBL475350 0.91 KMT2A (1.00) KDM4EMAPTKMT2AMEN1LMNA
Dl-Tryptophan SCHEMBL475349 0.91 KMT2A (1.00) KDM4EMAPTKMT2AMEN1LMNA
Dl-Tryptophan SCHEMBL19161120 0.91 KMT2A (1.00) KDM4EMAPTKMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012166842-A1 INCREASING PRODUCT YIELD AND/OR THROUGHPUT BY SUPERSATURATION OF SUBSTRATE CARGILL, INCORPORATED (US) 2012-12-06 WO disclosed
EP-2519406-A1 A POLYMER AND METHODS OF PREPARING AND USING A POLYMER Cargill, Incorporated (US) 2012-11-07 EP disclosed
WO-2011082353-A1 SEPARATION AND PURIFICATION OF MONATIN CARGILL, INCORPORATED (US) 2011-07-07 WO disclosed
WO-2011082351-A1 A POLYMER AND METHODS OF PREPARING AND USING A POLYMER CARGILL, INCORPORATED (US) 2011-07-07 WO disclosed
WO-2011082365-A2 IMPROVED BIOREACTOR PERFORMANCE IN THE PRODUCTION OF MONATIN CARGILL, INCORPORATED (US) 2011-07-07 WO disclosed
EP-2038405-A2 METHODS AND SYSTEMS FOR INCREASING PRODUCTION OF EQUILIBRIUM REACTIONS Cargill Incorporated (US) 2009-03-25 EP disclosed
WO-2007140195-A2 METHODS AND SYSTEMS FOR INCREASING PRODUCTION OF EQUILIBRIUM REACTIONS CARGILL, INCORPORATED (US) 2007-12-06 WO disclosed
EP-0937156-A2 PREPARATION OF D-AMINO ACIDS BY DIRECT FERMENTATIVE MEANS MONSANTO COMPANY (US) 1999-08-25 EP disclosed
WO-1998014602-A2 PREPARATION OF D-AMINO ACIDS BY DIRECT FERMENTATIVE MEANS NSC TECHNOLOGIES LLC (US) 1998-04-09 WO disclosed