Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9981149 | 0.84 | MEN1 (0.42) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL9981159 | 0.83 | PDE10A (0.39) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL1701334 | 0.83 | PDE10A (0.47) | PDE10AMAPK8 | |
| SCHEMBL1703500 | 0.81 | PDE10A (0.41) | PDE10AMEN1KMT2APOLBMAPK1 | |
| SCHEMBL12045528 | 0.80 | ALDH1A1 (0.50) | MEN1KMT2AAR | |
| SCHEMBL1701241 | 0.80 | EGFR (0.38) | PDE10AMEN1KMT2AARMAPK1 | |
| SCHEMBL9980990 | 0.80 | PDE10A (0.44) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL9981652 | 0.80 | ALDH1A1 (0.43) | PDE10A | |
| SCHEMBL1704471 | 0.77 | PDE10A (0.37) | PDE10AMEN1KMT2AARMAPK1 | |
| SCHEMBL12045585 | 0.77 | PDE10A (0.37) | PDE10AMEN1KMT2APOLBAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2020-02-26 | — | — | EP | disclosed |