Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.67 |
| ▸ | RAB9A | P51151 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.65 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.65 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.65 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.65 |
| ▸ | CBFB | Q13951 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.57 |
| ▸ | LDHA | P00338 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8355880 | 0.88 | NPC1 (0.68) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL5189057 | 0.85 | NPC1 (0.65) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL13609776 | 0.84 | NPC1 (0.61) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL24894010 | 0.84 | NPC1 (0.63) | NPC1RAB9AKDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8353649 | 0.83 | NPC1 (0.50) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL17432454 | 0.83 | KDM4E (0.65) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL13594195 | 0.82 | KDM4E (0.63) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL29728207 | 0.81 | NPC1 (0.67) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL28787648 | 0.81 | NPC1 (0.67) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL28623250 | 0.80 | RAB9A (0.66) | NPC1RAB9AKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288015-A1 | M6PR CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES | LYCIA THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |
| CN-109265451-B | Butyrylcholinesterase selective inhibitor and preparation method and application thereof | 中国药科大学 | 2022-07-15 | — | — | CN | disclosed |
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| US-20110172203-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | ARQULE, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| EP-1285651-B1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | TAKEDA PHARMACEUTICAL (JP) | 2010-09-01 | — | — | EP | disclosed |
| US-6930185-B2 | Melanin-concentrating hormone antagonist | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-16 | — | — | US | disclosed |
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-22 | — | — | US | disclosed |
| EP-1285651-A1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-26 | — | — | EP | disclosed |
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |
| EP-0276842-B1 | SILVER HALIDE PHOTOGRAPHIC MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-5035993-A | Quaternary ammonium salt nucleating agent | FUJI PHOTO FILM CO., LTD. (JP) | 1991-07-30 | — | — | US | disclosed |
| US-4877723-A | EMULSION LAYER CONTAINING AN ALKYNYL-SUBSTITUTED HETEROCYCLIC QUATERNARY AMMONIUM SALT; DIRECT POSITIVES; REVERSAL | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| US-4859579-A | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-08-22 | — | — | US | disclosed |
| US-4828973-A | DIRECT POSITIVES WITH REVERSAL PROPERTIES | FUJI PHOTO FILM CO., LTD. (JP) | 1989-05-09 | — | — | US | disclosed |
| EP-0276842-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | MCHR1, MC1R, MCHR2 | NPC1 1013/4885RAB9A 1132/4885KDM4E 2403/4885 |
| US-20110172203-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | MKI67, CDK4, ABL1 | NPC1 1758/4885RAB9A 2076/4885KDM4E 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.