Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 7/20 | 0.44 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21763692 | 0.99 | BACE1 (0.58) | BACE1IDO1SLC11A2CYP2D6TP53 | |
| SCHEMBL13007602 | 0.80 | BACE1 (0.77) | BACE1IDO1SLC11A2CYP2D6TP53 | |
| Hydrochloric Acid SCHEMBL2891486 | 0.78 | BACE1 (0.75) | BACE1IDO1SLC11A2CYP2D6TP53 | |
| Bromide SCHEMBL20920184 | 0.76 | BACE1 (0.67) | BACE1IDO1SLC11A2CYP2D6TP53 | |
| Thiourea SCHEMBL21751250 | 0.76 | SLC6A2 (0.39) | BACE1SMN1; SMN2ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL22275785 | 0.74 | BACE1 (0.69) | BACE1IDO1SLC11A2CYP2D6TP53 | |
| SCHEMBL18150337 | 0.74 | SLC6A2 (0.46) | SMN1; SMN2TAAR1ALDH1A1LMNASLC6A2 | |
| SCHEMBL16797182 | 0.74 | SLC6A2 (0.46) | SMN1; SMN2TAAR1ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL30540309 | 0.74 | KMT2A (0.46) | SMN1; SMN2ALDH1A1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL18149715 | 0.71 | SLC6A2 (0.46) | SMN1; SMN2TAAR1ALDH1A1LMNASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200060276-A1 | THIAZOLE COMPOUND AND HERBICIDE | OAT AGRIO CO., LTD. (JP) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200060276-A1 | THIAZOLE COMPOUND AND HERBICIDE | OR10J3, OXSR1, OXER1 | SLC6A2 3745/4885SLC6A4 1895/4885BACE1 4263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.