SCHEMBL21753396

SCHEMBL21753396

CCn1nc(C)cc1C(=O)Nc1nc2cc(C(N)=O)cc3c2n1C(C)(C)CO3

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 18/20 0.56
TBK1 Q9UHD2 1/20 0.53
ENPP1 P22413 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21753394 0.91 STING1 (0.54) STING1TBK1ENPP1
SCHEMBL30882065 0.91 STING1 (0.54) STING1TBK1ENPP1
SCHEMBL21766106 0.91 STING1 (0.55) STING1TBK1ENPP1
SCHEMBL21766327 0.90 STING1 (0.53) STING1TBK1ENPP1
SCHEMBL21753415 0.87 STING1 (0.51) STING1TBK1ENPP1
SCHEMBL21753433 0.87 STING1 (0.55) STING1TBK1ENPP1
SCHEMBL21766138 0.86 STING1 (0.51) STING1TBK1ENPP1
SCHEMBL21766149 0.85 ENPP1 (0.48) STING1TBK1ENPP1
SCHEMBL23585738 0.85 STING1 (0.52) STING1ENPP1
SCHEMBL24467551 0.84 STING1 (0.58) STING1TBK1ENPP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240287093-A1 HIGH ACTIVITY STING PROTEIN AGONIST ADLAI NORTYE BIOPHARMA CO., LTD. (CN) 2024-08-29 US disclosed
EP-3842437-B1 HIGH ACTIVITY STING PROTEIN AGONIST ADLAI NORTYE BIOPHARMA CO LTD (CN) 2024-04-10 EP disclosed
CN-111386275-B High activity STING protein agonists 杭州阿诺生物医药科技有限公司 2023-03-10 CN disclosed
EP-3842437-A1 HIGH ACTIVITY STING PROTEIN AGONIST Adlai Nortye Biopharma Co., Ltd. (CN) 2021-06-30 EP disclosed
EP-3842437-A1 HIGH ACTIVITY STING PROTEIN AGONIST Adlai Nortye Biopharma Co., Ltd. (CN) 2021-06-30 EP disclosed
CN-111386275-A High activity STING protein agonists 杭州阿诺生物医药科技有限公司 2020-07-07 CN disclosed
WO-2020038387-A1 HIGH ACTIVITY STING PROTEIN AGONIST 杭州阿诺生物医药科技有限公司 2020-02-27 WO disclosed
WO-2020038387-A1 HIGH ACTIVITY STING PROTEIN AGONIST 杭州阿诺生物医药科技有限公司 2020-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287093-A1 HIGH ACTIVITY STING PROTEIN AGONIST STING1, IRF3, MAVS STING1 1/4885TBK1 5/4885ENPP1 1547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.