Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.72 |
| ▸ | BRD4 | O60885 | 14/20 | 0.72 |
| ▸ | BRDT | Q58F21 | 11/20 | 0.72 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.68 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.68 |
| ▸ | RAD52 | P43351 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.67 |
| ▸ | CLK2 | P49760 | 3/20 | 0.67 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.67 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.67 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.67 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.67 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.67 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.67 |
| ▸ | PRKCG | P05129 | 2/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.67 |
| ▸ | NEK4 | P51957 | 2/20 | 0.67 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.67 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21755701 | 0.90 | PLK1 (0.66) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL21755692 | 0.88 | PLK1 (0.68) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL2400870 | 0.86 | BRD4 (0.81) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL13870847 | 0.86 | BRD4 (0.81) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL618594 | 0.86 | BRD4 (0.81) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL617519 | 0.85 | PLK1 (0.75) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL10098799 | 0.85 | PLK1 (0.75) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL21755709 | 0.85 | PLK1 (0.77) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1202517 | 0.84 | PLK1 (0.94) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL4304198 | 0.82 | PLK1 (0.73) | PLK1BRD4BRDTPLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570154-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570154-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders | BRSK2, STK3, BRSK1 | PLK1 110/4885BRD4 614/4885BRDT 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.