Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28111818 | 0.84 | KDM5A (0.35) | KDM5AMEN1HPGDKMT2AMIF | |
| SCHEMBL17065274 | 0.78 | KDM5A (0.37) | KDM5AMEN1HPGDKMT2AMIF | |
| SCHEMBL10026473 | 0.78 | MME (0.39) | KDM5AMEN1HPGDKMT2ADYRK1A | |
| SCHEMBL25332845 | 0.77 | MEN1 (0.41) | KDM5AMEN1HPGDKMT2AMIF | |
| SCHEMBL26664690 | 0.77 | TSHR (0.50) | GSK3BMEN1HPGDKMT2ALMNA | |
| SCHEMBL2810761 | 0.77 | ADORA2A (0.40) | KDM5AMEN1HPGDKMT2ADYRK1A | |
| SCHEMBL1431340 | 0.74 | KMT2A (0.44) | KDM5AMEN1KMT2ALMNARAF1 | |
| SCHEMBL12777937 | 0.74 | DYRK1A (0.40) | KDM5AMEN1HPGDKMT2ADYRK1A | |
| SCHEMBL1058997 | 0.73 | CYP1A2 (0.49) | HPGDLMNATSHRMAPTSMN1; SMN2 | |
| SCHEMBL10121089 | 0.72 | CA12 (0.44) | MEN1KMT2ANPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020041562-A1 | SUBSTITUTED IMIDAZOLES FOR THE INHIBITION OF TGF-BETA AND METHODS OF TREATMENT | CLAVIUS PHARMACEUTICALS, LLC (US) | 2020-02-27 | — | — | WO | disclosed |