Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.61 |
| ▸ | JAK2 | O60674 | 17/20 | 0.61 |
| ▸ | TYK2 | P29597 | 10/20 | 0.61 |
| ▸ | JAK3 | P52333 | 8/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21757113 | 0.89 | JAK1 (0.61) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757168 | 0.88 | JAK1 (0.62) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23424188 | 0.87 | JAK1 (0.57) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23424173 | 0.85 | JAK1 (0.75) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757104 | 0.85 | JAK1 (0.45) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757166 | 0.83 | JAK1 (0.56) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23584395 | 0.81 | JAK1 (0.68) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23424216 | 0.79 | JAK1 (0.54) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL30927825 | 0.78 | JAK1 (0.54) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21242706 | 0.77 | JAK1 (0.67) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020038457-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUND AS JAK INHIBITOR AND APPLICATION THEREOF | 珠海联邦制药股份有限公司 | 2020-02-27 | — | — | WO | disclosed |
| US-9403829-B2 | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2016-08-02 | — | — | US | disclosed |