Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.56 |
| ▸ | JAK2 | O60674 | 19/20 | 0.56 |
| ▸ | TYK2 | P29597 | 13/20 | 0.56 |
| ▸ | JAK3 | P52333 | 13/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23424188 | 0.93 | JAK1 (0.57) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757010 | 0.92 | JAK1 (0.53) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23424216 | 0.87 | JAK1 (0.54) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23424176 | 0.84 | JAK1 (0.49) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21242708 | 0.84 | JAK1 (0.76) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757171 | 0.83 | CYP11B2 (0.39) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757168 | 0.83 | JAK1 (0.62) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757112 | 0.83 | JAK1 (0.61) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23584395 | 0.82 | JAK1 (0.68) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL21757113 | 0.82 | JAK1 (0.61) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964616-A | Synthesis method and application of JAK inhibitor drug compound | 珠海联邦制药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117924272-A | Synthesis method and application of JAK inhibitor drug intermediate | 珠海联邦制药股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4108664-A1 | CRYSTALLINE FORM OF JAK INHIBITOR AND APPLICATION THEREOF | Zhuhai United Laboratories Co., Ltd (CN) | 2022-12-28 | — | — | EP | disclosed |
| EP-4105214-A1 | USE OF JAK INHIBITORS IN PREPARATION OF DRUGS FOR TREATING JAK KINASE-RELATED DISEASES | Zhuhai United Laboratories Co., Ltd (CN) | 2022-12-21 | — | — | EP | disclosed |
| WO-2022161205-A1 | ORAL PREPARATION CONTAINING JAK INHIBITOR OR SALT THEREOF OR CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 珠海联邦制药股份有限公司 | 2022-08-04 | — | — | WO | disclosed |
| WO-2021159372-A1 | USE OF JAK INHIBITORS IN PREPARATION OF DRUGS FOR TREATING JAK KINASE-RELATED DISEASES | 珠海联邦制药股份有限公司 | 2021-08-19 | — | — | WO | disclosed |
| WO-2020038457-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUND AS JAK INHIBITOR AND APPLICATION THEREOF | 珠海联邦制药股份有限公司 | 2020-02-27 | — | — | WO | disclosed |