Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.54 |
| ▸ | JAK3 | P52333 | 6/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | BLK | P51451 | 3/20 | 0.54 |
| ▸ | BMX | P51813 | 2/20 | 0.54 |
| ▸ | BTK | Q06187 | 6/20 | 0.51 |
| ▸ | CTSC | P53634 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.51 |
| ▸ | ITK | Q08881 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.51 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.51 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23049228 | 0.88 | EGFR (0.44) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21484367 | 0.87 | EGFR (0.51) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21484391 | 0.84 | EGFR (0.44) | EGFRCTSCNUAK1NUAK2KDR | |
| SCHEMBL21515951 | 0.82 | EGFR (0.49) | EGFRJAK3JAK2 | |
| SCHEMBL29538509 | 0.80 | JAK3 (0.46) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21484323 | 0.79 | EGFR (0.62) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21515827 | 0.78 | EGFR (0.52) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21758097 | 0.76 | EGFR (0.39) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21484370 | 0.75 | PIM1 (0.40) | ALK | |
| SCHEMBL29538822 | 0.75 | PIM1 (0.40) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062749-A1 | PYRROLO-AROMATIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | THE NATIONAL INSTITUTES OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT (NIP) (CN) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062749-A1 | PYRROLO-AROMATIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | BTK, SYK, ITK | EGFR 1705/4885JAK3 33/4885JAK2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.