Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23010845 | 0.80 | APP (0.64) | KDM4EDRD2SLC6A4APPCYP1A2 | |
| SCHEMBL21758401 | 0.78 | CYP1A2 (0.54) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL12367411 | 0.77 | IDO1 (0.54) | DRD2SLC6A4APPADRA1DIDO1 | |
| SCHEMBL8106285 | 0.76 | KDM4E (0.61) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL21758421 | 0.76 | DRD2 (0.69) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL4676876 | 0.76 | IDO1 (0.50) | DRD2SLC6A4APPADRA1DIDO1 | |
| SCHEMBL18324794 | 0.75 | IDO1 (0.47) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL12367426 | 0.74 | IDO1 (0.51) | DRD2SLC6A4APPADRA1DIDO1 | |
| SCHEMBL4676883 | 0.74 | HTR2C (0.62) | DRD2SLC6A4APPIDO1HTR2A | |
| SCHEMBL16801602 | 0.72 | KDM4E (0.70) | KDM4EBRD4ALDH1A1POLBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082802-B1 | TRYPTOPHAN-2,3-DIOXYGENASE (TDO) AND/OR INDOLAMINE-2,3-DIOXYGENASE (IDO) INHIBITORS AND THEIR USE | IOMET PHARMA LTD (GB) | 2020-02-26 | — | — | EP | disclosed |