SCHEMBL21758862

SCHEMBL21758862

CC(C)(C)c1cc(I)cc2ccc(F)cc12

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2A6 P11509 1/20 0.32
TNKS O95271 1/20 0.32
PARP1 P09874 1/20 0.32
TNKS2 Q9H2K2 1/20 0.32
MEN1 O00255 1/20 0.30
HCRTR1 O43613 1/20 0.30
KMT2A Q03164 1/20 0.30
DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21788088 0.80 SMN1; SMN2 (0.41) PTGS1PTGS2CYP1A2CYP2A6TNKS
SCHEMBL21758861 0.80 CYP1A2 (0.38) PTGS1PTGS2CYP1A2CYP2A6
SCHEMBL25700442 0.79 BACE1 (0.34) PTGS1PTGS2CYP1A2CYP2A6TNKS
SCHEMBL24630602 0.79 ALDH1A1 (0.41) PTGS1PTGS2CYP1A2CYP2A6TNKS
SCHEMBL21085333 0.76 ALDH1A1 (0.37) CYP1A2CYP2A6MEN1KMT2A
SCHEMBL28386866 0.74 NQO1 (0.35) CYP2A6
SCHEMBL27117088 0.74 CYP1A2 (0.43) PTGS1PTGS2CYP1A2CYP2A6TNKS
SCHEMBL15709742 0.69 ALDH1A1 (0.36) PTGS1PTGS2CYP1A2MEN1KMT2A
SCHEMBL21260717 0.69 PTGS1 (0.39) PTGS1PTGS2CYP1A2CYP2A6MEN1
SCHEMBL24061881 0.67 AR (0.43) PTGS2CYP1A2MEN1KMT2ADHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4206210-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2023-07-05 EP disclosed
EP-3613751-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2020-02-26 EP disclosed