Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 7/20 | 0.74 |
| ▸ | PSMB11 | A5LHX3 | 6/20 | 0.74 |
| ▸ | PSMA7 | O14818 | 6/20 | 0.74 |
| ▸ | PSMB1 | P20618 | 6/20 | 0.74 |
| ▸ | PSMA1 | P25786 | 6/20 | 0.74 |
| ▸ | PSMA2 | P25787 | 6/20 | 0.74 |
| ▸ | PSMA3 | P25788 | 6/20 | 0.74 |
| ▸ | PSMA4 | P25789 | 6/20 | 0.74 |
| ▸ | PSMB8 | P28062 | 6/20 | 0.74 |
| ▸ | PSMB9 | P28065 | 6/20 | 0.74 |
| ▸ | PSMA5 | P28066 | 6/20 | 0.74 |
| ▸ | PSMB4 | P28070 | 6/20 | 0.74 |
| ▸ | PSMB6 | P28072 | 6/20 | 0.74 |
| ▸ | PSMB10 | P40306 | 6/20 | 0.74 |
| ▸ | PSMB3 | P49720 | 6/20 | 0.74 |
| ▸ | PSMB2 | P49721 | 6/20 | 0.74 |
| ▸ | PSMA6 | P60900 | 6/20 | 0.74 |
| ▸ | PSMA8 | Q8TAA3 | 6/20 | 0.74 |
| ▸ | PSMB7 | Q99436 | 6/20 | 0.74 |
| ▸ | LONP1 | P36776 | 11/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10344951 | 0.85 | PSMB5 (1.00) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL18175253 | 0.83 | PSMB5 (0.95) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL18175249 | 0.80 | PSMB5 (0.84) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL8190135 | 0.80 | PSMB11 (0.61) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL13593756 | 0.78 | KDM4E (0.59) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL12340819 | 0.78 | PSMB5 (0.79) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL18175254 | 0.77 | PSMB5 (0.66) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL22757737 | 0.77 | PSMB8 (0.58) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL8187046 | 0.77 | PSMB11 (0.58) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL8185208 | 0.77 | PSMB11 (0.58) | PSMB5PSMB11PSMA7PSMB1PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371203-B1 | BORTEZOMIB CONJUGATES AND METHODS USING SAME | UNIV ROCHESTER (US) | 2020-02-26 | — | — | EP | disclosed |