Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9981415 | 0.91 | PDE10A (0.37) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL1699296 | 0.85 | PDE10A (0.41) | PDE10AMEN1KMT2APOLBPABPC1 | |
| Water SCHEMBL15643684 | 0.84 | PDE10A (0.41) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL1702837 | 0.79 | NCOA3 (0.37) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL9980990 | 0.79 | PDE10A (0.44) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL9982053 | 0.78 | PDE10A (0.41) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL1702361 | 0.77 | BRAF (0.39) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL9980859 | 0.77 | PDE10A (0.46) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL1699325 | 0.76 | PDE10A (0.42) | PDE10AMEN1KMT2APOLBPABPC1 | |
| SCHEMBL7703884 | 0.76 | LMNA (0.36) | PDE10AMEN1KMT2APOLBPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2020-02-26 | — | — | EP | disclosed |