SCHEMBL2176028

SCHEMBL2176028

O=c1ccn([C@@H]2O[C@H](C(F)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 13/20 0.57
P2RY6 Q15077 7/20 0.57
P2RY4 P51582 4/20 0.53
P2RY14 Q15391 4/20 0.53
SLC28A1 O00337 1/20 0.52
SLC28A2 O43868 1/20 0.52
SLC29A1 Q99808 1/20 0.52
SLC28A3 Q9HAS3 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2800171 0.91 P2RY2 (0.61) P2RY2P2RY6P2RY4P2RY14
SCHEMBL18770063 0.90 P2RY2 (0.62) P2RY2P2RY6P2RY4P2RY14
SCHEMBL607048 0.90 P2RY2 (0.62) P2RY2P2RY6P2RY4P2RY14
SCHEMBL11688923 0.87 P2RY2 (0.53) P2RY2P2RY6P2RY4P2RY14SLC28A1
SCHEMBL18007470 0.86 P2RY2 (0.57) P2RY2P2RY6P2RY4P2RY14SLC28A1
SCHEMBL15643790 0.85 SLC28A1 (0.55) P2RY2P2RY6P2RY4P2RY14SLC28A1
SCHEMBL15643275 0.85 SLC28A1 (0.55) P2RY2P2RY6P2RY4P2RY14SLC28A1
SCHEMBL1704984 0.84 P2RY2 (0.54) P2RY2P2RY6P2RY4P2RY14SLC28A1
Phosphoric Acid SCHEMBL9576797 0.83 P2RY2 (0.53) P2RY2P2RY6P2RY4P2RY14SLC28A1
SCHEMBL1585708 0.82 SLC28A1 (0.60) P2RY2P2RY6P2RY4P2RY14SLC28A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12357617-B2 Discovery of novel anti-infectives for gram negative pathogens THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-07-15 US disclosed
US-12325859-B2 Microbial approach for the production of long chain compounds UT-BATTELLE, LLC (US) 2025-06-10 US disclosed
CN-114206896-B Cyclic deoxyribonucleotide compounds 纽科利制药公司 2024-12-17 CN disclosed
EP-3538151-B1 HUMAN PLASMA-LIKE MEDIUM WHITEHEAD INST BIOMEDICAL RES (US) 2024-06-26 EP disclosed
CN-117563014-A Antibody-drug gene conjugate and application thereof 上海交通大学 2024-02-20 CN disclosed
EP-3250693-B2 PROTEIN DELIVERY IN PRIMARY HEMATOPOIETIC CELLS UNIV CALIFORNIA (US) 2023-12-20 EP disclosed
US-20230056452-A1 MICROBIAL APPROACH FOR THE PRODUCTION OF LONG CHAIN COMPOUNDS U.S. DEPARTMENT OF ENERGY 2023-02-23 US disclosed
US-20230051644-A1 HUMAN PLASMA-LIKE MEDIUM WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH 2023-02-16 US disclosed
WO-2023018718-A1 MICROBIAL APPROACH FOR THE PRODUCTION OF LONG CHAIN COMPOUNDS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2023-02-16 WO disclosed
US-11453858-B2 Human plasma-like medium WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2022-09-27 US disclosed
EP-1100964-A1 GENE SEQUENCE VARIANCES WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE Variagenics, Inc. (US) 2001-05-23 EP disclosed
WO-2000004194-A1 GENE SEQUENCE VARIANCES WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE VARIAGENICS, INC. (US) 2000-01-27 WO disclosed
US-5968914-A Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides PRO-NEURON, INC. (US) 1999-10-19 US disclosed
US-5859295-A Canavanine analogs and their use as chemotherapeutic agents UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 1999-01-12 US disclosed
EP-0831849-A1 METHODS OF REDUCING TOXICITY OF CHEMOTHERAPEUTIC AND ANTIVIRAL AGENTS WITH ACYLATED PYRIMIDINE NUCLEOSIDES PRO-NEURON, INC. (US) 1998-04-01 EP disclosed
WO-1996040165-A1 METHODS OF REDUCING TOXICITY OF CHEMOTHERAPEUTIC AND ANTIVIRAL AGENTS WITH ACYLATED PYRIMIDINE NUCLEOSIDES PRO-NEURON, INC. (US) 1996-12-19 WO disclosed
EP-0746336-A1 PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS IGEN, INC. (US) 1996-12-11 EP disclosed
US-5552440-A Use of L-canavanine as a chemotherapeutic agent for the treatment of pancreatic cancer THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 1996-09-03 US disclosed
EP-0746336-A4 PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS IGEN INC (US) 1996-07-26 EP disclosed
WO-1993002703-A1 PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS IGEN, INC. (US) 1993-02-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12357617-B2 Discovery of novel anti-infectives for gram negative pathogens BET1, BOLA2; BOLA2B, BRD2 P2RY2 2202/4885P2RY6 3919/4885P2RY4 3264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.