Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.52 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | BMX | P51813 | 3/20 | 0.37 |
| ▸ | TEC | P42680 | 2/20 | 0.37 |
| ▸ | BLK | P51451 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21761347 | 0.95 | BTK (0.53) | BTKJAK3FGFR4CCNKCDK12 | |
| SCHEMBL21747910 | 0.89 | BTK (0.47) | BTKJAK3FGFR4CCNKCDK12 | |
| SCHEMBL21747787 | 0.89 | BTK (0.47) | BTKJAK3FGFR4CCNKCDK12 | |
| SCHEMBL21761221 | 0.86 | BTK (0.45) | BTKJAK3FGFR4CCNKCDK12 | |
| SCHEMBL21761227 | 0.86 | JAK3 (0.53) | BTKJAK3FGFR4CCNKCDK12 | |
| SCHEMBL24699679 | 0.85 | FGFR4 (0.50) | BTKJAK3FGFR4EGFRITK | |
| SCHEMBL21747846 | 0.84 | ERBB2 (0.49) | BTKJAK3FGFR4EGFRMTOR | |
| SCHEMBL21761312 | 0.84 | FGFR4 (0.43) | BTKJAK3FGFR4CCNKCDK12 | |
| SCHEMBL29700820 | 0.84 | ERBB2 (0.49) | BTKJAK3FGFR4EGFRMTOR | |
| SCHEMBL21747991 | 0.84 | BTK (0.48) | BTKJAK3FGFR4CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807274-B1 | 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER | LEAD DISCOVERY CENTER GMBH (DE) | 2022-07-27 | — | — | EP | disclosed |
| WO-2020039060-A1 | 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER | LEAD DISCOVERY CENTER GMBH (DE) | 2020-02-27 | — | — | WO | disclosed |
| EP-3613738-A1 | 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER | Lead Discovery Center GmbH (DE) | 2020-02-26 | — | — | EP | disclosed |