Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 5/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 13/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747995 | 0.90 | FGFR4 (0.49) | FGFR4JAK3EGFRITKALK | |
| SCHEMBL21747911 | 0.90 | FGFR4 (0.48) | FGFR4JAK3EGFRITKALK | |
| SCHEMBL21761299 | 0.87 | FGFR4 (0.46) | FGFR4JAK3EGFRITKALK | |
| SCHEMBL21760329 | 0.85 | BTK (0.52) | FGFR4JAK3EGFRITKBTK | |
| SCHEMBL21761373 | 0.84 | EGFR (0.41) | FGFR4JAK3EGFRALKBTK | |
| SCHEMBL21747832 | 0.84 | FGFR4 (0.44) | FGFR4JAK3EGFRITKALK | |
| SCHEMBL30090199 | 0.84 | ERBB2 (0.47) | FGFR4JAK3EGFRALKMAPKAPK2 | |
| SCHEMBL21747968 | 0.84 | ERBB2 (0.47) | FGFR4JAK3EGFRALKMAPKAPK2 | |
| SCHEMBL30090257 | 0.84 | FGFR4 (0.44) | FGFR4JAK3EGFRITKALK | |
| SCHEMBL21761347 | 0.83 | BTK (0.53) | FGFR4JAK3EGFRALKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807274-B1 | 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER | LEAD DISCOVERY CENTER GMBH (DE) | 2022-07-27 | — | — | EP | disclosed |