Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21761372 | 0.87 | EGFR (0.69) | EGFRERBB2KDREPHB4 | |
| SCHEMBL21761244 | 0.85 | EGFR (0.63) | EGFRERBB2EPHA2KDREPHB4 | |
| SCHEMBL17821491 | 0.85 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL16399318 | 0.85 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL17821485 | 0.85 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL21748179 | 0.85 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL17821484 | 0.85 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL16398581 | 0.85 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL28412069 | 0.83 | EGFR (0.76) | EGFRERBB2 | |
| SCHEMBL21761408 | 0.82 | EGFR (0.82) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022186-B1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS THEREOF, AND USE AS PHARMACEUTICALS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2020-02-26 | — | — | EP | disclosed |