Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.63 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
| ▸ | FBP1 | P09467 | 2/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.56 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21761372 | 0.88 | EGFR (0.69) | EGFRERBB2KDREPHB4FBP1 | |
| SCHEMBL18632967 | 0.87 | FBP1 (0.76) | EGFRERBB2KDREPHB4FBP1 | |
| SCHEMBL18862875 | 0.87 | EGFR (0.75) | EGFRERBB2KDREPHB4FBP1 | |
| SCHEMBL19125553 | 0.86 | EGFR (0.63) | EGFRERBB2KDREPHB4FBP1 | |
| SCHEMBL18862743 | 0.86 | EGFR (0.79) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL21761309 | 0.85 | EGFR (0.66) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL1190546 | 0.84 | EGFR (0.68) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL6989211 | 0.84 | EGFR (0.68) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL1418419 | 0.84 | EGFR (0.74) | EGFRERBB2ERBB4ERBB3DUS2 | |
| SCHEMBL1418417 | 0.84 | EGFR (0.74) | EGFRERBB2ERBB4ERBB3DUS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022186-B1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS THEREOF, AND USE AS PHARMACEUTICALS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2020-02-26 | — | — | EP | disclosed |