Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.51 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7621269 | 0.88 | CDK8 (0.65) | CYP2A6CDK8CHEK1AURKADAPK3 | |
| SCHEMBL10857362 | 0.87 | HDAC1 (0.60) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL10855370 | 0.84 | HDAC1 (0.49) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL2009820 | 0.82 | DYRK1A (0.56) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL160500 | 0.81 | CDK8 (0.49) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL2012989 | 0.80 | HDAC1 (0.54) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL844056 | 0.80 | BCL2L1 (0.58) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL28769185 | 0.79 | DAPK3 (0.76) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL2010041 | 0.78 | HDAC1 (0.49) | HDAC1HDAC3HDAC2NCOR2CYP2A6 | |
| SCHEMBL21470630 | 0.78 | DYRK1A (0.49) | HDAC1HDAC3HDAC2NCOR2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079804-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-07-07 | — | — | WO | disclosed |