Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | F9 | P00740 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL791586 | 0.82 | MAOB (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL257758 | 0.79 | NR4A2 (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL4638867 | 0.79 | MAOB (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL26377963 | 0.79 | NR4A2 (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL12269215 | 0.79 | NR4A2 (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL9812484 | 0.79 | NR4A2 (0.69) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL23118 | 0.78 | ABCB1 (0.53) | MAOBSPHK2SPHK1IDO1F9 | |
| SCHEMBL7170719 | 0.77 | NR4A2 (0.71) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL21762 | 0.76 | NR4A2 (0.66) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL22316 | 0.76 | MAOB (0.66) | NR4A2MAOBMAOASPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |