Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 8/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17213085 | 0.83 | HSD17B10 (0.41) | GRK6ALOX15HSD17B10KDM4EMAPK14 | |
| SCHEMBL17212977 | 0.80 | GRK6 (0.56) | GRK6ALOX15HSD17B10 | |
| SCHEMBL21763955 | 0.78 | GRK6 (0.44) | GRK6KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14907799 | 0.76 | GRK6 (0.64) | GRK6HSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL16171061 | 0.76 | GRK6 (0.52) | GRK6KDM4EALDH1A1 | |
| SCHEMBL14907763 | 0.76 | GRK6 (0.64) | GRK6KDM4EALDH1A1 | |
| SCHEMBL21763968 | 0.76 | STK17B (0.38) | GRK6KDM4EMAPK14ALDH1A1 | |
| SCHEMBL18552387 | 0.74 | SMN1; SMN2 (0.41) | GRK6HSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL21763928 | 0.74 | GRK6 (0.46) | GRK6KDM4EENPP1ALDH1A1 | |
| SCHEMBL14907789 | 0.74 | GRK6 (0.66) | GRK6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134390-B1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-02-26 | — | — | EP | disclosed |