SCHEMBL21764556

SCHEMBL21764556

C1=CC2Oc3c(-c4ccc(Nc5ccc(-c6ccccc6)cc5)cc4)cccc3C2C=C1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.32
HTR2B P41595 3/20 0.32
HTR1A P08908 2/20 0.32
HTR7 P34969 2/20 0.32
TMEM97 Q5BJF2 2/20 0.32
SIGMAR1 Q99720 2/20 0.32
STK10 O94804 1/20 0.30
SLK Q9H2G2 1/20 0.30
EPHX2 P34913 1/20 0.30
ALDH1A1 P00352 1/20 0.30
ALOX15 P16050 1/20 0.30
TSHR P16473 1/20 0.30
ALOX12 P18054 1/20 0.30
PTGS1 P23219 1/20 0.30
SLC6A2 P23975 1/20 0.30
MAPK1 P28482 1/20 0.30
PTGS2 P35354 1/20 0.30
HSD17B10 Q99714 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22452204 0.89 ENPP1 (0.36) ALDH1A1ALOX15
SCHEMBL8302403 0.89 HTR2B (0.36) HTR2BHTR1AHTR7TMEM97SIGMAR1
SCHEMBL22106380 0.85 HTR7 (0.32) HTR2BHTR1AHTR7TMEM97SIGMAR1
SCHEMBL22994374 0.84
SCHEMBL23224683 0.82 PDK2 (0.35)
SCHEMBL23316120 0.80 EDNRB (0.30)
SCHEMBL19622728 0.80
SCHEMBL23921290 0.79 KDM4E (0.40) ALDH1A1TSHRMAPK1HSD17B10TDP1
SCHEMBL21861098 0.78 MEN1 (0.33)
SCHEMBL22994171 0.78 FABP3 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3227269-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2020-02-26 EP disclosed