Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21764675 | 0.89 | POLB (0.46) | GPR119SSTR4POLBPDE4APDE4B | |
| SCHEMBL10116593 | 0.82 | GPR119 (0.61) | GPR119 | |
| SCHEMBL21752528 | 0.82 | GPR119 (0.55) | GPR119POLB | |
| SCHEMBL17672409 | 0.80 | PIK3CD (0.56) | GPR119 | |
| SCHEMBL10116785 | 0.79 | GPR119 (0.42) | GPR119 | |
| SCHEMBL10134616 | 0.74 | GPR119 (0.47) | GPR119 | |
| SCHEMBL30153517 | 0.72 | SSTR4 (0.75) | SSTR4SSTR1 | |
| SCHEMBL11361492 | 0.72 | GPR119 (0.57) | GPR119POLB | |
| SCHEMBL17499841 | 0.72 | POLB (0.40) | GPR119SSTR4POLBSSTR1 | |
| SCHEMBL17455965 | 0.72 | GPR119 (0.46) | GPR119PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020041100-A1 | NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-27 | — | — | WO | disclosed |