Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31436622 | 0.95 | IRAK4 (0.61) | IRAK4 | |
| SCHEMBL26598605 | 0.95 | IRAK4 (0.61) | IRAK4 | |
| SCHEMBL21379161 | 0.90 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL18882610 | 0.90 | IRAK4 (0.64) | IRAK4 | |
| SCHEMBL18341624 | 0.89 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL21379077 | 0.89 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL16873174 | 0.89 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL21379047 | 0.89 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL15714717 | 0.88 | IRAK4 (0.56) | IRAK4 | |
| SCHEMBL16873243 | 0.88 | IRAK4 (0.56) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089973-B1 | HETEROARYL SUBSTITUTED NICOTINAMIDE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-04-29 | — | — | EP | disclosed |
| EP-3475270-B1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-02-26 | — | — | EP | disclosed |