Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14881458 | 0.89 | IRAK4 (0.47) | IRAK4PIM1AAK1DYRK3CCNT1 | |
| SCHEMBL14881490 | 0.89 | IRAK4 (0.47) | IRAK4PIM1AAK1DYRK3CCNT1 | |
| SCHEMBL21765944 | 0.88 | IRAK4 (0.48) | IRAK4PIM1AAK1NTRK1TGFBR1 | |
| SCHEMBL18654925 | 0.88 | IRAK4 (0.48) | IRAK4PIM1AAK1NTRK1TGFBR1 | |
| SCHEMBL18654880 | 0.88 | IRAK4 (0.48) | IRAK4PIM1AAK1NTRK1TGFBR1 | |
| SCHEMBL14881882 | 0.83 | IRAK4 (0.49) | IRAK4PIM1NTRK1 | |
| SCHEMBL14881846 | 0.82 | IRAK4 (0.50) | IRAK4PIM1NTRK1TGFBR1TGFBR2 | |
| SCHEMBL18654317 | 0.82 | IRAK4 (0.44) | IRAK4PIM1AAK1NTRK1NTRK3 | |
| SCHEMBL14897276 | 0.82 | IRAK4 (0.53) | IRAK4PIM1AAK1NTRK1NTRK3 | |
| SCHEMBL14896633 | 0.82 | IRAK4 (0.44) | IRAK4PIM1AAK1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |