Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14896633 | 1.00 | IRAK4 (0.44) | IRAK4NPC1RAB9ARXFP1KDM4E | |
| SCHEMBL21637228 | 0.84 | NPC1 (0.58) | IRAK4NPC1RAB9ARXFP1KDM4E | |
| SCHEMBL14881458 | 0.83 | IRAK4 (0.47) | IRAK4AAK1NTRK1DPP4PIM1 | |
| SCHEMBL14881490 | 0.83 | IRAK4 (0.47) | IRAK4AAK1NTRK1DPP4PIM1 | |
| SCHEMBL21765966 | 0.82 | IRAK4 (0.46) | IRAK4AAK1NTRK1PIM1NTRK3 | |
| SCHEMBL21765944 | 0.82 | IRAK4 (0.48) | IRAK4AAK1NTRK1PIM1TGFBR1 | |
| SCHEMBL18654880 | 0.82 | IRAK4 (0.48) | IRAK4AAK1NTRK1PIM1TGFBR1 | |
| SCHEMBL18654925 | 0.82 | IRAK4 (0.48) | IRAK4AAK1NTRK1PIM1TGFBR1 | |
| SCHEMBL14881882 | 0.78 | IRAK4 (0.49) | IRAK4NPC1RAB9AKMT2ANTRK1 | |
| SCHEMBL21765939 | 0.78 | PDE10A (0.44) | IRAK4KDM4EAAK1NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022234287-A1 | IMIDAZOPYRIDAZINE DERIVATIVES USEFUL AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2022-11-10 | — | — | WO | disclosed |
| WO-2021148807-A1 | PHARMACEUTICAL COMPOSITIONS AND THEIR USES | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2021098745-A1 | PREPARATION AND APPLICATION OF A CLASS OF PROTEIN RECEPTOR KINASE INHIBITORS | 上海轶诺药业有限公司 | 2021-05-27 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020016594-A1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-01-23 | — | — | WO | disclosed |
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |