Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21767034 | 1.00 | APLNR (0.45) | APLNRCA2CA1LMNACA9 | |
| SCHEMBL18254244 | 0.79 | APLNR (0.46) | APLNRCA2CA1LMNACA9 | |
| SCHEMBL18254253 | 0.79 | APLNR (0.46) | APLNRCA2CA1LMNACA9 | |
| SCHEMBL18254245 | 0.79 | APLNR (0.46) | APLNRCA2CA1LMNACA9 | |
| SCHEMBL18474669 | 0.76 | APLNR (0.44) | APLNRCA2CA1LMNACA9 | |
| SCHEMBL18474670 | 0.76 | APLNR (0.44) | APLNRCA2CA1LMNACA9 | |
| SCHEMBL18254622 | 0.76 | APLNR (0.44) | APLNRCA2CA1LMNACA9 | |
| SCHEMBL21767039 | 0.73 | APLNR (0.42) | APLNRCA2CA1CA9 | |
| SCHEMBL21766996 | 0.73 | APLNR (0.42) | APLNRCA2CA1CA9 | |
| SCHEMBL21708252 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3300500-B9 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3300500-B1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-02-26 | — | — | EP | disclosed |