Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 1.00 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.88 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.88 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.85 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 3/20 | 0.82 |
| ▸ | PKM | P14618 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | HTT | P42858 | 3/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29800540 | 1.00 | NPC1 (1.00) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL10055020 | 0.93 | NPC1 (0.94) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL4251968 | 0.92 | RXFP1 (0.94) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL30862297 | 0.92 | RXFP1 (0.94) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL4253111 | 0.91 | TRPV1 (1.00) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL4256368 | 0.90 | NPC1 (1.00) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL5226157 | 0.90 | NPC1 (1.00) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL4252397 | 0.88 | NPC1 (0.83) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL31179863 | 0.88 | NPC1 (0.83) | NPC1RAB9ANLRP3KCNK9KCNK3 | |
| SCHEMBL4252236 | 0.87 | RXFP1 (0.79) | NPC1RAB9ANLRP3KCNK9KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015193229-A1 | BET-PROTEIN INHIBITING 1,4-DIHYDROPYRIDO[3,4-B]PYRAZINONES WITH META-SUBSTITUTED AROMATIC AMINO- OR ETHER GROUPS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-12-23 | — | — | WO | claimed |
| EP-1928879-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | Brystol-Myers Squibb Company (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007038314-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-05 | — | — | WO | claimed |
| CN-1155278-A | Arylthio compounds as antibacteral and antiviral agents | WARNER LAMBERT CO (US) | 1997-07-23 | — | — | CN | claimed |
| US-20250179031-A1 | PROTEASOME ENHANCERS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2025-06-05 | — | — | US | disclosed |
| CN-110483582-B | Aza-carbene-palladium complex crystal, synthesis method thereof and application thereof in preparing amide compound | 陕西师范大学 | 2023-02-10 | — | — | CN | disclosed |
| CN-114805112-A | PDE2 inhibitor amide derivative and preparation method thereof | 常州大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-110483582-A | Azepine Cabbeen palladium complex crystal and its synthetic method and preparing the application in amide compound | UNIV SHAANXI NORMAL | 2019-11-22 | — | — | CN | disclosed |
| CN-109457268-A | A kind of method of electro-catalysis benzamide compound synthesis benzoxazoles | 福建医科大学 | 2019-03-12 | — | — | CN | disclosed |
| CN-109369555-A | A kind of method of microwave radiation benzamide compound synthesis benzoxazoles in water phase | 福建医科大学 | 2019-02-22 | — | — | CN | disclosed |
| WO-2017197088-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS | PHARMAKEA, INC. (US) | 2017-11-16 | — | — | WO | disclosed |
| US-8349836-B2 | Phthalazine derivatives as inhibitors of protein kinase | ARALDI GIAN-LUCA (US) | 2013-01-08 | — | — | US | disclosed |
| US-20030203906-A1 | A phenylamide derivatives for treating gastrointestinal reflux disorders, eating disorder obesity and irritable bowel disorder | JOHNSON SIGMONG G (US) | 2003-10-30 | — | — | US | disclosed |
| CN-1440390-A | Substituted diamine derivatives as motilin antagonists | ORTHO MCNEIL PHARM INC (US) | 2003-09-03 | — | — | CN | disclosed |
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6511980-B2 | For therapy of gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel disorder | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2003-01-28 | — | — | US | disclosed |
| US-20020013352-A1 | For therapy of gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel disorder | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-01-31 | — | — | US | disclosed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | disclosed |
| CN-1155278-A | Arylthio compounds as antibacteral and antiviral agents | WARNER LAMBERT CO (US) | 1997-07-23 | — | — | CN | disclosed |
| EP-0602242-A1 | BENZISOXAZOLE COMPOUND AND USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250179031-A1 | PROTEASOME ENHANCERS AND USES THEREOF | PSME3, PSMG3, PSME1 | NPC1 2258/4885RAB9A 2779/4885NLRP3 1366/4885 |
| US-20020013352-A1 | For therapy of gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel disorder | MLNR, GIPR, NPY1R | NPC1 3669/4885RAB9A 440/4885NLRP3 1989/4885 |
| US-20030203906-A1 | A phenylamide derivatives for treating gastrointestinal reflux disorders, eating disorder obesity and irritable bowel disorder | MLNR, GIPR, NPY1R | NPC1 3268/4885RAB9A 504/4885NLRP3 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.