Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Penicillamine SCHEMBL6333584 | 1.00 | PTGS1 (0.67) | PTGS1ALDH1A1MAPTSLC7A11GSR | |
| Penicillamine SCHEMBL6333581 | 1.00 | PTGS1 (0.67) | PTGS1ALDH1A1MAPTSLC7A11GSR | |
| Penicillamine SCHEMBL22124996 | 0.85 | PTGS1 (0.72) | PTGS1ALDH1A1MAPTSLC7A11GSR | |
| Dl-Penicillamine SCHEMBL22124997 | 0.85 | PTGS1 (0.72) | PTGS1ALDH1A1MAPTSLC7A11GSR | |
| Dl-Penicillamine SCHEMBL4261009 | 0.85 | PTGS1 (0.72) | PTGS1ALDH1A1MAPTSLC7A11GSR | |
| Penicillamine SCHEMBL7170074 | 0.85 | PTGS1 (0.72) | PTGS1ALDH1A1MAPTSLC7A11GSR | |
| Glutamic Acid SCHEMBL4261156 | 0.84 | GRM8 (0.64) | PTGS1ALDH1A1MAPTGSRGRM8 | |
| Penicillamine SCHEMBL11222229 | 0.83 | PTGS1 (0.69) | PTGS1ALDH1A1MAPTSLC7A11GSR | |
| Dl-Penicillamine SCHEMBL16011677 | 0.82 | ALDH1A1 (0.62) | PTGS1ALDH1A1MAPTGSRCYP1A2 | |
| Penicillamine SCHEMBL16011676 | 0.82 | ALDH1A1 (0.62) | PTGS1ALDH1A1MAPTGSRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113388007-A | Ultra-pure agonists of guanylate cyclase C, methods of making and using the same | 博士医疗爱尔兰有限公司 | 2021-09-14 | — | — | CN | disclosed |
| EP-2825188-B1 | FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHODS OF USE | BAUSCH HEALTH IRELAND LTD (IE) | 2020-03-04 | — | — | EP | disclosed |
| CN-108676076-A | The method for preparing guanosine cyclic mono-phosphate agonist | 辛纳吉制药公司 | 2018-10-19 | — | — | CN | disclosed |
| CN-107090016-A | The method for preparing guanosine cyclic mono-phosphate activator | 辛纳吉制药公司 | 2017-08-25 | — | — | CN | disclosed |