SCHEMBL21768545

SCHEMBL21768545

CC(C)(C)c1ccc(-c2nc(-c3ccc(C(C)(C)C)cc3)nc(-c3ccc4[nH]c5ccccc5c4c3)n2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 6/20 0.65
HDAC6 Q9UBN7 1/20 0.48
TP53 P04637 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
RAB9A P51151 2/20 0.44
NPC1 O15118 1/20 0.44
TNKS O95271 2/20 0.44
TNKS2 Q9H2K2 2/20 0.44
AHR P35869 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
HSD17B10 Q99714 1/20 0.42
GABRP O00591 3/20 0.40
GABRD O14764 3/20 0.40
GABRA1 P14867 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27242060 0.86 KIF11 (0.75) KIF11HDAC6TNKSTNKS2AHR
SCHEMBL29563904 0.86 KIF11 (0.75) KIF11HDAC6TNKSTNKS2AHR
SCHEMBL19914872 0.86 KIF11 (0.75) KIF11HDAC6TNKSTNKS2AHR
SCHEMBL29513071 0.85 AHR (0.52) KIF11SMN1; SMN2AHRMEN1KMT2A
SCHEMBL20210403 0.85 AHR (0.52) KIF11SMN1; SMN2AHRMEN1KMT2A
SCHEMBL15786396 0.81 AHR (0.47) KIF11AHRMEN1KMT2AKDM4E
SCHEMBL24126494 0.81 KIF11 (0.57) KIF11HDAC6TNKSTNKS2ABCG2
SCHEMBL30282204 0.81 KIF11 (0.57) KIF11HDAC6TNKSTNKS2ABCG2
SCHEMBL16809116 0.80 AHR (0.50) KIF11AHRMEN1KMT2AKDM4E
SCHEMBL29363588 0.80 KIF11 (1.00) KIF11AHRMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617290-B1 ORGANIC MOLECULES FOR OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2022-03-09 EP disclosed
EP-3617290-A1 ORGANIC MOLECULES FOR OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-03-04 EP disclosed