Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.67 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200852 | 0.87 | MET (0.58) | METPDGFRBPDGFRAFGFR2PTK2 | |
| SCHEMBL21769156 | 0.87 | MET (0.71) | METPDGFRBPDGFRAFGFR2 | |
| SCHEMBL22407346 | 0.87 | MET (0.71) | METPDGFRBPDGFRAFGFR2 | |
| SCHEMBL21966347 | 0.86 | MET (1.00) | METPDGFRA | |
| SCHEMBL20782537 | 0.86 | MET (0.69) | METPDGFRBPDGFRAFGFR2 | |
| SCHEMBL21769367 | 0.85 | PDGFRB (0.64) | METPDGFRBPDGFRAFGFR2 | |
| SCHEMBL3904910 | 0.84 | PDGFRA (0.70) | METPDGFRBPDGFRAFGFR2 | |
| SCHEMBL7480761 | 0.84 | FGFR2 (0.78) | PDGFRBPDGFRAFGFR2 | |
| SCHEMBL3895466 | 0.84 | PDGFRB (0.70) | METPDGFRBPDGFRAFGFR2 | |
| SCHEMBL22703856 | 0.83 | PDGFRB (0.68) | METPDGFRBPDGFRAFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842425-A1 | NOVEL QUINOLINE DERIVATIVE INHIBITOR | Nanjing Transthera Biosciences Co., Ltd. (CN) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020141470-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2020-07-09 | — | — | WO | disclosed |
| WO-2020038460-A1 | NOVEL QUINOLINE DERIVATIVE INHIBITOR | 南京药捷安康生物科技有限公司 | 2020-02-27 | — | — | WO | disclosed |