Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255155 | 0.86 | BTK (0.43) | BTKSYKFGRSRCTEC | |
| SCHEMBL255495 | 0.82 | BTK (0.46) | BTKSYKFGRSRCTEC | |
| SCHEMBL14912114 | 0.79 | BTK (0.42) | BTKSYK | |
| SCHEMBL16357030 | 0.78 | BTK (0.47) | BTKSYKFGRSRCTEC | |
| SCHEMBL10262845 | 0.78 | BTK (0.49) | BTKSYKFGRSRCTEC | |
| SCHEMBL24375396 | 0.77 | SYK (0.61) | BTKSYK | |
| SCHEMBL25013719 | 0.77 | SYK (0.44) | BTKSYK | |
| SCHEMBL174117 | 0.75 | BTK (0.49) | BTKSYKFGRSRCTEC | |
| SCHEMBL14929644 | 0.74 | BTK (0.44) | BTKSYKFGRSRCTEC | |
| SCHEMBL19981572 | 0.74 | BTK (0.44) | BTKSYKFGRSRCTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062769-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | GENENTECH, INC. (US) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062769-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | PDXK, BTK, TYK2 | BTK 2/4885SYK 32/4885FGR 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.