SCHEMBL21769826

SCHEMBL21769826

Brc1cccc(-n2c(-c3ccccc3)nc3cc(-c4ccccc4)ccc32)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DCTPP1 Q9H773 1/20 0.47
ESR1 P03372 1/20 0.45
ESR2 Q92731 1/20 0.45
SIRT2 Q8IXJ6 2/20 0.44
SIRT1 Q96EB6 2/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
GAA P10253 2/20 0.43
ALDH1A1 P00352 2/20 0.42
HDAC1 Q13547 2/20 0.41
HDAC8 Q9BY41 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
PLAUR Q03405 1/20 0.41
LMNA P02545 2/20 0.40
ABCG2 Q9UNQ0 1/20 0.40
MAPT P10636 3/20 0.40
HSD17B10 Q99714 2/20 0.39
HSP90AA1 P07900 1/20 0.39
ATM Q13315 1/20 0.39
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17943149 0.93 ESR1 (0.49) DCTPP1ESR1ESR2SIRT2SIRT1
SCHEMBL29992246 0.89 ESR1 (0.50) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL28653866 0.89 ESR1 (0.50) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL8512875 0.87 ESR1 (0.58) DCTPP1ESR1ESR2MEN1KMT2A
SCHEMBL16116627 0.86 ESR1 (0.58) DCTPP1ESR1ESR2SIRT2SIRT1
SCHEMBL338245 0.84 ESR1 (0.54) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL20776101 0.84 SIRT2 (0.46) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL12912581 0.83 SIRT2 (0.50) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL13067727 0.82 SIRT2 (0.52) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL20776098 0.82 SIRT2 (0.52) ESR1ESR2SIRT2SIRT1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020040434-A1 NOVEL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE USING SAME 주식회사 엘지화학 2020-02-27 WO disclosed