SCHEMBL338245

SCHEMBL338245

Brc1ccc2c(c1)nc(-c1ccccc1)n2-c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.54
ESR2 Q92731 1/20 0.54
SIRT2 Q8IXJ6 2/20 0.48
SIRT1 Q96EB6 2/20 0.48
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
ATM Q13315 1/20 0.47
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.45
HDAC1 Q13547 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HCAR1 Q9BXC0 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
ADORA2A P29274 1/20 0.44
ADORA2B P29275 1/20 0.44
ADORA1 P30542 1/20 0.44
HSD17B10 Q99714 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
PDE10A Q9Y233 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12912581 0.95 SIRT2 (0.50) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL29992246 0.90 ESR1 (0.50) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL28653866 0.90 ESR1 (0.50) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL17943149 0.88 ESR1 (0.49) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL18314223 0.88 ESR1 (0.54) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL12912585 0.87 ESR1 (0.45) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL21769826 0.84 DCTPP1 (0.47) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL29991475 0.83 PDE10A (0.48) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL16440841 0.83 PDE10A (0.48) ESR1ESR2SIRT2SIRT1MEN1
SCHEMBL338139 0.83 ALDH1A1 (0.68) MEN1KMT2AALDH1A1HCAR1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12297191-B2 Heterocyclic derivative and organic electroluminescent device thereof CHANGCHUN HYPERIONS TECHNOLOGY CO., LTD (CN) 2025-05-13 US disclosed
CN-114573593-B Dicarbazole compound, intermediate, organic electroluminescent device and display device 阜阳欣奕华材料科技有限公司 2024-05-14 CN disclosed
US-11665961-B2 Heterocyclic compound and organic light emitting device using same LT MATERIALS CO., LTD. (KR) 2023-05-30 US disclosed
US-11665961-B2 Heterocyclic compound and organic light emitting device using same LT MATERIALS CO., LTD. (KR) 2023-05-30 US disclosed
CN-113735835-B Compound, organic electroluminescent device and display device 阜阳欣奕华材料科技有限公司 2022-12-06 CN disclosed
CN-114573593-A Dicarbazole compound, intermediate, organic electroluminescent device and display device 阜阳欣奕华材料科技有限公司 2022-06-03 CN disclosed
US-20220173333-A1 HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE THEREOF CHANGCHUN HYPERIONS TECHNOLOGY CO., LTD (CN) 2022-06-02 US disclosed
EP-4006025-A1 HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE THEREOF Changchun Hyperions Technology Co., Ltd. (CN) 2022-06-01 EP disclosed
CN-112442023-B Heterocyclic derivative and organic electroluminescent device thereof 长春海谱润斯科技股份有限公司 2021-08-24 CN disclosed
CN-112442023-A Heterocyclic derivative and organic electroluminescent device thereof 长春海谱润斯科技股份有限公司 2021-03-05 CN disclosed
WO-2007106503-A2 COMBINED TREATMENT WITH AN EGFR KINASE INHIBITOR AND AN AGENT THAT SENSITIZES TUMOR CELLS TO THE EFFECTS OF EGFR KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2007-09-20 WO disclosed
WO-2007106503-A2 COMBINED TREATMENT WITH AN EGFR KINASE INHIBITOR AND AN AGENT THAT SENSITIZES TUMOR CELLS TO THE EFFECTS OF EGFR KINASE INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2007-09-20 WO disclosed
US-20070200490-A1 Nitrogenous Heterocycle Derivative, And Organic Electroluminescent Element Employing The Same IDEMITSU KASON CO.LTD (JP) 2007-08-30 US disclosed
WO-2007061737-A2 FUSED BICYCLIC mTOR INHIBITORS OSI PHARMACEUTICALS, INC. (US) 2007-05-31 WO disclosed
US-20070112005-A1 mammalian Target Of Rapamycin (mTOR) kinase; for treatment of lymphoma or ovarian cancer OSI PHARMACEUTICALS, INC. 2007-05-17 US disclosed
US-20070112005-A1 mammalian Target Of Rapamycin (mTOR) kinase; for treatment of lymphoma or ovarian cancer OSI PHARMACEUTICALS, INC. 2007-05-17 US disclosed
US-20070112005-A1 mammalian Target Of Rapamycin (mTOR) kinase; for treatment of lymphoma or ovarian cancer OSI PHARMACEUTICALS, INC. 2007-05-17 US disclosed
EP-1734038-A1 NITROGENOUS HETEROCYCLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2006-12-20 EP disclosed
US-20060147747-A1 2-[4-(10-naphthalene-2-yl-anthracene-9-yl)-phenyl]-1-phenyl-1H-benzimidazole; elevation of luminance and of efficiency in light emission even under low driving voltage IDEMITSU KOSAN CO., LTD. (JP) 2006-07-06 US disclosed
EP-1602648-A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2005-12-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070200490-A1 Nitrogenous Heterocycle Derivative, And Organic Electroluminescent Element Employing The Same RPS3A, NCOA3, HNRNPA0 ESR1 10/4885ESR2 41/4885SIRT2 2419/4885
US-20220173333-A1 HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE THEREOF KCNH1, OCIAD2, ETFB ESR1 330/4885ESR2 449/4885SIRT2 1172/4885
US-20070112005-A1 mammalian Target Of Rapamycin (mTOR) kinase; for treatment of lymphoma or ovarian cancer MTOR, MAPKAP1, RPS6KA1 ESR1 2744/4885ESR2 2259/4885SIRT2 2034/4885
US-11665961-B2 Heterocyclic compound and organic light emitting device using same CRY1, CYP1B1, CRY2 ESR1 319/4885ESR2 1073/4885SIRT2 2247/4885
US-12297191-B2 Heterocyclic derivative and organic electroluminescent device thereof KCNH1, OCIAD2, ETFB ESR1 330/4885ESR2 449/4885SIRT2 1172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.